Transaminases Applied to the Synthesis of High Added-Value Enantiopure Amines
نویسندگان
چکیده
منابع مشابه
A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines†
Transaminase enzymes have significant potential for the sustainable synthesis of amines using mild aqueous reaction conditions. Here a metagenomics mining strategy has been used for new transaminase enzyme discovery. Starting from oral cavity microbiome samples, DNA sequencing and bioinformatics analyses were performed. Subsequent in silico mining of a library of contiguous reads built from the...
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The four-step conversion of a series of N-Boc-protected l-amino acid methyl esters into enantiopure N-Boc allylamines by a modified Julia olefination is described. Key steps include the reaction of a lithiated phenylalkylsulfone with amino esters, giving chiral β-ketosulfones, and the reductive elimination of related α-acetoxysulfones. The overall transformation takes place under mild condition...
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ژورنال
عنوان ژورنال: Organic Process Research & Development
سال: 2014
ISSN: 1083-6160,1520-586X
DOI: 10.1021/op4003104